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Jane's Office:
713-348-3704
Lab:
713-348-3707
Student Office 223:
713-348-3006
Student Office 125:
713-348-4345
Fax:
713-348-5877
Mail
Department of
Bioengineering, MS 142
Rice University
PO Box 1892
Houston, TX
77251-1892
Copyright © 2005-2008
Jane Grande-Allen.
All Rights Reserved
This page maintained by:
Martin Bost
mbost@alumni.rice.edu
2008
• Gupta V, Werdenberg JA, Mendez JS, Grande-Allen KJ: Influence of strain on proteoglycan synthesis by valvular interstitial cells in 3D culture. Acta Biomaterialia, 4(1):88-96, 2008.
• Nistri S, Grande-Allen KJ , Noale M, Basso C, Maggi S, Thiene G: Aortic elasticity and size in bicuspid aortic valve syndrome, Eur Heart J, 29 ( 4 ): 472-9 , 2008.
• Blevins TL, Peterson SB, Lee EL, Bailey A, Frederick JD, Gupta V, Grande-Allen KJ: Mitral valvular interstitial cells demonstrate regional, adhesional, and synthetic heterogeneity. Cells Tissues Organs, 187(2):113-122, 2008.
• Saraf A, Hacker MC, Sitharaman B, Grande-Allen KJ , Barry MA, Mikos AG: Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules, 9:818-827, 2008.
• Ferdous Z, Lazaro LD, Iozzo RV, Höök M, Grande-Allen KJ: Influence of cyclic strain and decorin deficiency on 3-D cellularized collagen matrices . Biomaterials, 29:2740-8, 2008.
• Hahn MS, Grande-Allen KJ: Analysis of glycosaminoglycan composition of the vocal fold lamina propria in relation to function. Ann Otol Rhinol Laryngol, in press, 2008.
• Gupta V, Werdenberg JA, Lawrence BD, Stephens EH, Mendez JS, Grande-Allen KJ: Reversible synthesis of glycosaminoglycans and proteoglycans by cyclically stretched valvular interstitial cells in 3D culture. Ann Biomed Eng, in press, 2008.
• Stephens ES, Chu CK, Grande-Allen KJ: Valve proteoglycan content and glycosaminoglycan fine structure are unique to microstructure, mechanical loads, and age: relevance to an age-specific tissue engineered heart valve. Acta Biomaterialia, in press, 2008.
• Allison DD, Wight TN , Ripp NJ , Braun KR, Grande-Allen KJ: Endogenous overexpression of hyaluronan synthases within dynamically cultured collagen gels: implications for vascular and valvular disease. Biomaterials, in press, 2008.
• Stephens EH, Nguyen TC, Itoh A, Ingels Jr NB, Miller DC, Grande-Allen KJ: The effects of mitral regurgitation alone are sufficient for leaflet remodeling. Circulation, accepted, 2008.
• Gupta V, Barzilla JE, Mendez JS, Stephens EH, Lee EL, Collard CD, Laucirica R, Weigel PH, Grande-Allen KJ: Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves. Cardiovasc Pathol, accepted, 2008.
2007
• Gupta V, Werdenberg J, Blevins TL, Grande-Allen KJ: Synthesis of glycosaminoglycans in differently loaded regions of collagen gels seeded with valvular interstitial cells. Tissiue Eng, 13(1):41-49, 2007.
• Ferdous Z, Grande-Allen KJ: Utility and control of proteoglycan in tissue engineering. Tissue Eng, 13(8):1893-904, 2007.
• Stephens ES, Carroll JL, Grande-Allen KJ: The use of collagenase III for the isolation of porcine aortic valvular interstitial cells: rationale and optimization . J Heart Valve Dis, 16:175-183, 2007.
• Grande-Allen KJ , Osman N, Ballinger ML, Dadlani H, Marasco S, Little P: Glycosaminoglycan synthesis and structure as targets for the prevention of calcific aortic valve disease. Cardiovasc Res, 76(1):19-28, 2007.
• Allison DD, Braun KR, Vasco N, Wight TN, Grande-Allen KJ: The effect of endogenous overexpression of hyaluronan synthases on material, morphological and biochemical properties of uncrosslinked collagen biomaterials. Biomaterials, 28:5509-5517, 2007.
• Stephens ES, Grande-Allen KJ: Age-related changes in collagen synthesis and turnover in porcine heart valves. J Heart Valve Dis, 16(6):672-82, 2007.
• Ferdous Z, Wei VM, Iozzo RV, Höök M, Grande-Allen KJ: Decorin-TGF-beta interaction regulates matrix organization and mechanical characteristics of 3-D collagen matrices. J Biol Chem, 282 (49): 35887-98 , 2007.
2006
• Allison DD. Grande-Allen KJ. Hyaluronan: A Powerful Tissue Engineering Tool. Tissue Engineering, 12(8):2131-40, 2006.
• Barzilla JE, Blevins TL, Grande-Allen KJ: Age-related structural changes in cardiac valves: implicatinos for tissue engineered repairs. Invited review for American Journal of Geriatric Cardiology, 15(5):311-5, 2006.
• Brown EN, Peterson ML, Grande-Allen KJ: Biological systems and materials: a review of the field of biomechanics and the role of the Society for Experimental Mechanics. Experimental Techniques, 30(2):21-30, 2006.
• Gupta V, Grande-Allen KJ: Effects of static vs. cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res, 72(3):375-383, 2006.
• Blevins TL, Carroll J, Raza A, Grande-Allen KJ: Phenotypic characterization of isolated valvular interstitial cell subpopulations. J Heart Valve Dis, 15(6):815-822, 2006.
2005
• Grande-Allen KJ, Borowski A, Troughton R, Houghtaling P, DiPaola N, Moravec CS, Vesely I, Griffin BP: Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements: an extracellular matrix and echocardiographic study. J Am Coll Cardiol, 45(1):54-61, 2005.
• Featured in accompanying editorial: O'Brien KD, Fishbein DP: Mitral valve abnormalities in congestive heart failure: an interplay between form and function? J Am Coll Cardiol, 45(1):62-64, 2005.
• Grande-Allen KJ, Barber JE, Klatka KM, Vesely I, Moravec CS, McCarthy PM: Mitral valve stiffening in end-stage heart failure: evidence of an organic contribution to functional mitral regurgitation. J Thorac Cardiovasc Surg, 130(3):783-790, 2005.
2004
• Allison DD, Drazba JA, Vesely I, Kader KN, Grande-Allen KJ: Cell viability mapping within long-term heart valve organ cultures. J Heart Valve Dis, 13(2):290-296, 2004.
• Grande-Allen KJ, Calabro A, Gupta V, Wight TN, Hascall VC, Vesely I: Glycosaminoglycans and proteoglycans in normal mitral valve leaflets and chordae: association with regions of tensile and compressive loading. Glycobiology, 14(7):621-633, 2004.
2003
• Grande-Allen KJ, Mako WJ, Calabro A, Ratliff NB, Vesely I: Loss of chondroitin 6-sulfate and hyaluronan from failed porcine bioprosthetic valves. J Biomed Mater Res, 65A(2):251-259, 2003.
• Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Rothman RB, Roth BL: 3,4-methylenedioxymethamphetamine, (MDMA, "Ecstasy") has fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro , Mol Pharmacol 63(6):1223-9, 2003.
• Grande-Allen KJ, Griffin BP, Ratliff NB, Cosgrove DM, Vesely I: Glycosaminoglycan profiles of myxomatous mitral leaflets and chordae parallel the severity of mechanical alterations. J Am Coll Cardiol, 42(2):271-7, 2003.
2002
• Sedransk K, Grande-Allen KJ, Vesely I: Failure mechanics of mitral valve chordae tendineae. J Heart Valve Dis, 11(5):644-650, 2002.
• Seidler DG, Breuer E, Grande-Allen KJ, Hascall VC, Kresse H: Core protein dependence of epimerization of glucuronosyl residues in galactosaminoglycans. J Biol Chem 277(44):42409-42416, 2002.
2001
• Grande-Allen KJ, Ratliff N, Griffin B, Cosgrove DM, Vesely I: Outer sheath rupture may precede complete chordal rupture in fibrotic mitral valve disease. J Heart Valve Dis, 10(1);90-93, 2001.
• Grande-Allen KJ, Griffin BP, Calabro A, Ratliff NB, Cosgrove DM III, Vesely I: Myxomatous mitral valve chordae II: Selective increase of glycosaminoglycans. J Heart Valve Dis, 10(3):325-333, 2001.
• Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Finite-element analysis of aortic valve-sparing: influence of graft shape and stiffness. IEEE Trans Biomed Eng, 48(6):647-659,2001.
• Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence: finite-element modeling of Marfan syndrome. J Thorac Cardiovasc Surg, 122:946-954, 2001.
2000
• Grande-Allen KJ, Cochran RP, Reinhall PG, Kunzelman KS: Re-creation of sinuses is important for sparing the aortic valve: a finite element study. J Thorac Cardiovasc Surg, 119(4 Pt 1):753-63, 2000.
• Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence: finite element modeling of aortic root dilatation. Ann Thorac Surg, 69(6):1851-1857, 2000.
Prior to 2000
• Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS: Mechanisms of aortic valve incompetence in aging: finite element modeling. J Heart Valve Dis, 8(2):149-156,1999.
• Grande KJ, Cochran RP, Reinhall PE, Kunzelman KD: Stress variations in the human aortic root and valve: the role of anatomic asymmetry. Ann Biomed Eng, 26(4):534-545, 1998.
• Patwardhan AR, Evans JM, Berk M, Grande KJ, Knapp CF: Spectral indices of cardiovascular adaptations to short term simulated microgravity exposure. Integr Physiol Behav Sci, 30(3):201-214, 1995.
• Kunzelman KS, Grande KJ, David TE, Cochran RP, Verrier ED: Aortic valve and root relationships: impact on surgical repair. J Thorac Cardiovasc Surg, 107:162-170, 1994.
• Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED: Porcine aortic leaflet arrangement may contribute to clinical xenograft failure. ASAIO J, 39:918-922, 1993.
• Grande-Allen KJ, Tissue engineering of heart valves , Biomedical Engineering Handbook, 3 rd Edition, CRC Press: Boca Raton, FL, 2006, pp. 57-1 – 57-19.
• Barzilla JE, Grande-Allen KJ : Design of splashing bioreactor maintaining mitral valve structure in vitro , Proceedings of the Society for Experimental Mechanics, Orlando FL , June 2008.
• Durst CA, Grande-Allen KJ : Design and development of an aortic valve culture system , Proceedings of the Society for Experimental Mechanics, Orlando FL , June 2008.
• Gheewala N, Grande-Allen KJ : Sterile flow loop design for mitral valve organ culture , Proceedings of the Soci ety for Experimental Mechanics, Orlando FL , June 2008.
• Barzilla JE, Grande-Allen KJ : Can LVADs restore normal mitral valve mechanics in heart failure? Proceedings of the Society for Experimental Mechanics, Portland OR , June 2005.
• Grande-Allen KJ, Lawrence BD, Gupta V: Tissue engineering tools for mechanical modulation of valvular extracellular matrix . Proceedings of the Society for Experimental Mechanics X International Congress & Exposition, Costa Mesa, CA, 2004.
• Grande-Allen KJ : Fibrotic vs. myxomatous remodeling of mitral valves. Proceedings of the IEEE-EMBS Annual Meeting, San Francisco , CA , 2004.
• Grande-Allen KJ , Vesely I, Hascall VC: Identification, localization, and function of proteoglycans in normal and diseased valves and valvular cell cultures , Proceedings of Hyaluronan 2003, Cleveland , OH , 2003.
